Dr. rer. nat. Sunil Yeruva

“Be and let others be happy!”

Ausbildung/Education:

June 1997- May 2000 Bachelor of Science, Nagarjuna University,Guntur,, India
July 2000-July 2002 Masters in Life Sciences, Devi Ahilya University, Indore, India
March 2004 - May 2007: Ph.D. in the Postgraduate Program - Cellular, Molecular and Clinical Biology of Internal Organs. Graduate College, GK 335. Department of Gastroenterology, Hepatology, and Endocrinology, Georg-August-University, Goettingen, Germany.
Project: The role of intestinal epithelium in IBD; effect of cytokines, glucocorticoids, and 5-HT on NFkB activation and chemokine gene expression."
June 2007 - January 2015: Post-doctoral fellow in Prof. Ursula Seidler’s Lab, Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.
Project: Molecular mechanisms involved in inflammation induced alterations in salt absorption in the intestine.
April 2015 - January 2016: Research Professional, Department of Pathology, University of Chicago. Project: Elucidating the role of claudin-2 in Inflammatory bowel disease pathogenesis and developing pharmacological approaches to modify claudin-2 for therapeutic benefit.
February 2016 – April 2017: Post-doctoral research fellow at Brigham and Women’s Hospital and Research fellow at Harvard medical school. Projects: Elucidating the role of claudin-2 in Inflammatory bowel disease pathogenesis and developing pharmacological approaches to modify claudin-2 for therapeutic benefit. 2. Characterization of environmental enteropathy children biopsies from Pakistan.
October 2017- till date Post-doctoral fellow at Anatomische Anstalt, Lehrstuhl I, LMU, Munich Project: Investigation of cell adhesion in cardiomyocytes.

Wissenschaftliche Schwerpunkte/ Research Interests

Regulation of cardiomyocyte cohesion and its implications in the outcome of Arrhythmogenic Cardiomyopathy

 

Lehrerfahrung/Teaching Experience

Macroscopic Anatomy ( Dissection ) and microscopic Anatomy
Supervision of MD- und PhD-students, Forschungsmodule students.

 

Drittmittel/ Research Grants

Friedrich-Bauer Stiftung research grant to work on ‘ Choliinergic signaling mediated cardiomyocyte cohesion’ in the year 2019
Hochschulinterne Förderung (an Intramural Research Grant) awarded by Hannover Medical School in the year 2011 to work on ‘PDZK1 transcriptional regulation during intestinal inflammation’. This grant led to a successful publication in the journal, Frontiers Physiology in 2017
Auszeichnungen und Mitgliedschaften/ Awards and Memberships
Member of German Anatomical Society
Member of European Society of Cardiology
Awarded travel grant by FASEB to attend ‘Gastrointestinal Tract XVI: GI homeostasis, the microbiome, and the barrier, development, and disease’ in Colorado, USA in August 2015
Awarded travel grant by “Physiological Society” to attend IUPS 2013 at Birmingham, UK in July 2013
Awarded travel grant by “Excellenzcluster Inflammation at Interfaces” to attend 4Th Annual Cluster Symposium Inflammation at Interfaces at Hamburg in February 2013
Awarded travel grant by “United European Gastroenterology” to attend UEG Basic science course, July 2012, Szeged, Budapest.
Review editor for Gastrointestinal sciences; Frontiers in Physiology

 

Publikationsverzeichnis

Originalartikel

Shoykhet M, Trenz S, Kempf E, Williams T, Gerull B, Schinner C, Yeruva S*, Waschke J*. Cardiomyocyte adhesion and hyperadhesion differentially require ERK1/2 and plakoglobin. JCI Insight.2020 Sep 17;5(18):140066. *shared corresponding authorship. (Immunostainings were published as cover page).

Schinner C, Olivares-Florez S, Schlipp A, Trenz S, Feinendegen M, Flaswinkel H, Kempf E, Egu DT, Yeruva S, Waschke J. The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner. Basic Res Cardiol. 2020 Jun 17;115(4):46. PMID: 32556797.

Yeruva S*, Kempf E*, Egu DT, Flaswinkel H, Kugelmann D, Waschke J. Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes. Front Physiol. 2020 May 21;11:430. PMID: 32508670. *shared first authorship

Schinner C*, Erber BM*, Yeruva S*, Schlipp A, Rötzer V, Kempf E, Kant S, Leube RE, Mueller TD, Waschke J. Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. JCI Insight. 2020 May 7;5(9):e130141. PMID: 32376797. *shared first authorship.

Ong MLDM*, Yeruva S*, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. Lab Invest. 2020 Mar;100(3):483-490. PMID: 31605016. *shared first authorship.

Luo M*, Yeruva S*, Liu Y, Chodisetti G, Riederer B, Menon MB, Tachibana K, Doi T, Seidler UE. IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes. Front Physiol. 2017 Feb 7;8:61. PMID: 28223944 * Shared first author.

Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, Lünnemann M, Goldstein J, Singh AK, Riederer B, Bachmann O, Bleich A, Gereke M, Bruder D, Hagen S, He P, Yun C, Seidler U. Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis. Pflugers Arch. 2015 Aug;467(8):1795-807. PMID: 25271043.

Farkas K, Yeruva S*, Rakonczay Z Jr, Ludolph L, Molnár T, Nagy F, Szepes Z, Schnúr A, Wittmann T, Hubricht J, Riederer B, Venglovecz V, Lázár G, Király M, Zsembery Á, Varga G, Seidler U, Hegyi P. New therapeutic targets in ulcerative colitis: the importance of ion transporters in the human colon. Inflamm Bowel Dis. 2011 Apr;17(4):884-98. PMID: 20722063. Shared first author.

Yeruva S*, Farkas K, Hubricht J, Rode K, Riederer B, Bachmann O, Cinar A, Rakonczay Z, Molnár T, Nagy F, Wedemeyer J, Manns M, Raddatz D, Musch MW, Chang EB, Hegyi P, Seidler U. Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis. Inflamm Bowel Dis. 2010 Jul;16(7):1149-61. PMID: 20027604. * Shared first author.

Lin S, Yeruva S*, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC. Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology. 2010 Feb;138(2):649-58.PMID: 19800338. * Shared first author

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