PhD Alexander García Ponce

"scio me nihil scire o scio me nescire - I know that I know nothing!" - Plato´s account about Socrates - Socratic Pardox

 

Ausbildung/Education:
2007-2011 Bachelor of Science in Chemistry and Pharmaceutical Biology, Universidad Autónoma de Guadalajara, Campus Tabasco, Mexico
2011-2013 Master of Science in Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico
2013-2017 PhD in Molecular Biomedicine Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico Project: “The role of cortactin and HS1 in vascular hyperpermeability during sepsis”
2018-till date Postdoctoral Fellow at the Anatomy Institute, Department I, Anatomy and Cell Biology from Ludwig Maximilian University, Munich, Germany

 

Wissenschaftliche Schwerpunkte/ Research Interests
Molecular mechanisms involved in the regulation of the endothelial and epithelial barrier during homeostasis and disease, under static conditions and flow.
Endothelial-Leukocytes cell-cell interactions and transmigration.
Molecular pathogenesis of systemic inflammatory diseases such as Sepsis.

 

Lehrerfahrung/Teaching Experience
Kursus der Makroskopischen Anatomie (Präparierkurs)
Supervision MD- und PhD-students, Forschungsmodulant*Innen

 

Drittmittel/ Research Grants
EKFS-2019_A176 "Role of actin-binding proteins in cAMP-mediated endothelial junction regulation and vascular permeability"

 

Leitung
Electric Cell-substrate Impedance Sensing (ECIS)
Laser Optical Tweezer
Flow System (shear stress)

 

Awards and Memberships
Mitglied der Deutschen Anatomischen Gesellschaft
seit 2013 Mitglied der American Society for Investigative Pathology (ASIP)
2014 Oral and Poster presentations “Cortactin deficiency causes increased ROCK1-mediated actin-contractility and decreased adrenomedullin secretion leading to enhanced endothelial permeability” at the Experimental Biology Annual Meeting of the ASIP (American Society for Investigative Pathology), San Diego, CA. Histochemical Society Trainee Travel Award 2014
2015 Poster presentation “Cortactin deficiency causes increased ROCK1-mediated
actin-contractility and decreased adrenomedullin secretion leading to
enhanced endothelial permeability”
at the Pathobiology for Investigators, Students and Academicians, Baltimore, MD.}American Society for Investigative Pathology Trainee Travel Award 2015
2016 Poster presentation “Cortactin deficiency causes increased ROCK1-mediated actin-contractility and decreased adrenomedullin secretion leading to enhanced endothelial permeability” at the Experimental Biology Annual Meeting of the ASIP (American Society for Investigative Pathology) at San Diego, CA. American Society for Investigative Pathology Trainee Travel Award 2016

 

Publikationsverzeichnis

Originalartikel

Hilda Vargas Robles, Alí Francisco Citalán Madrid, Alexander García Ponce, Angelica Silva Olivares, Mineko Shibayama, Abigail Betanzos, Porfirio Nava & Michael Schnoor. Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage. Oxid Med Cell Longev 2016

Alexander García Ponce, Alí F. Citalán Madrid, HildaVargas Robles, SandraChánez Paredes, Porfirio Nava, Abigail Betanzos, Alexander Zarbock, Klemens Rottner, DietmarVestweber & Michael Schnoor. Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility. Scientific Reports 6, e 29003 (2016)

A F Citalán-Madrid, H Vargas-Robles, A García-Ponce, M Shibayama, A Betanzos, P Nava, C Salinas-Lara, K Rottner, R Mennigen and M Schnoor. Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis. Mucosal Immunology 2017, 10(5):1237-1247

Kugelmann, D., L. T. Rotkopf, M. Y. Radeva, A. Garcia-Ponce, E. Walter and J. Waschke (2018). "Histamine causes endothelial barrier disruption via Ca(2+)-mediated RhoA activation and tension at adherens junctions." Sci Rep 8(1): 13229.

Eduardo Vadillo, Sandra Chánez-Paredes, Hilda Vargas-Robles, Idaira María Guerrero-Fonseca, Ramón Castellanos-Martínez, Alexander García-Ponce, Porfirio Nava, Daniel Alberto Girón-Pérez, Leopoldo Santos-Argumedo and Michael Schnoor. Intermittent rolling is a new defect of the extravasation cascade caused by Myosin1edeficiency in neutrophils. PNAS 2019, 116 (52) 26752-26758.

Timo Rademakers, Marieke Goedhart, Mark Hoogenboezem, Alexander García Ponce, Jos van Rijssel, Maryna Samus, Michael Schnoor, Stefan Butz, Stephan Huveneers, Dietmar Vestweber,, Martijn A. Nolte, Carlijn Voermans and Jaap D. van Buul. Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium. Haemotologica 2020, doi: 10.3324/haematol.2018.196329

García-Ponce, A.; Schuster, K.; Døskeland, S.-O.; Reed, R.K.; Curry, F.-R.E.; Waschke, J.; Radeva, M.Y. Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1. Cells 2020, 9, 2170.

Alexander García-Ponce, Eduardo Vadillo, Idaira M. Guerrero-Fonseca, Nathaniel L. Lartey, Sandra Chánez-Paredes, Hilda Vargas-Robles, Mineko Shibayama, Porfirio Nava, Michael Schnoor. HS1 deficiency protects against sepsis by attenuating neutrophil recruitment into the lung. Ready for submission

Book Chapter and Reviews
A.F. Citalán-Madrid, A. García-Ponce, H. Vargas-Robles, A. Betanzos & M. Schnoor. Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms. Tissue Barriers 2013, 1(5):e26938.

Garcia-Ponce, A., A. F. Citalan-Madrid, M. Velazquez-Avila, H. Vargas-Robles and M. Schnoor (2015). "The role of actin-binding proteins in the control of endothelial barrier integrity." Thromb Haemost 113(1): 20-36.

Garcia-Ponce, A., S. Chanez Paredes, K. F. Castro Ochoa and M. Schnoor (2016). "Regulation of endothelial and epithelial barrier functions by peptide hormones of the adrenomedullin family." Tissue Barriers 4(4): e1228439.

Michael Schnoor, Alexander García-Ponce, Eduardo Vadillo, Rosana Pelayo, Jan Rossaint, Alexander Zarbock. Actin dynamics in the regulation of endothelial barrier functions and neutrophil recruitment during endotoxemia and sepsis. Cellular and Molecular Life Sciences 2017, 74(11):1-13.